期刊
DRUG DISCOVERY TODAY
卷 14, 期 23-24, 页码 1130-1135出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2009.08.006
关键词
-
资金
- NIGMS NIH HHS [R01 GM073857, R01 GM073857-04] Funding Source: Medline
Given the key roles of integral membrane proteins as transporters and channels, it is necessary to understand their structures and, hence, mechanisms and regulation at the molecular level. Membrane proteins represent similar to 30% of all proteins of currently sequenced genomes. Paradoxically, however, only similar to 2% of crystal structures deposited in the protein data bank are of membrane proteins, and very few of these are at high resolution (better than 2 angstrom). The great disparity between our understanding of soluble proteins and our understanding of membrane proteins is because of the practical problems of working with membrane proteins - specifically, difficulties in expression, purification and crystallization. Thus, computational modeling has been utilized extensively to make crucial advances in understanding membrane protein structure and function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据