期刊
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
卷 37, 期 12, 页码 1446-1454出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/03639045.2011.584387
关键词
Biodegradable polymers; buccal; formulation; hydrogels; in vitro models; mechanical properties; natural products; polymeric drug delivery systems; viscosity
Purpose: Binary polymeric systems containing poloxamer 407 (P407) and Carbopol 934P (C934P) were designed to deliver propolis extract (PE) or sildenafil citrate for the endodontic treatment (pulp protection). Methods: Gelation temperature, rheology (flow), bioadhesion, and in vitro drug release of formulations were determined. Results: Formulations showed thermoresponsive behavior, existing as a liquid at room temperature and gel at 34-37 degrees C. In addition, they exhibited pseudoplastic flow and low degrees of thixotropy or rheopexy. The greatest bioadhesion was noted in the formulation containing 20% P407 (w/w) and 0.10% C934P (w/w). PE release from formulation containing 15% P407 (w/w) and 0.25% C934P (w/w) was controlled by the phenomenon of relaxation of polymer chains. Moreover, sildenafil release from formulation containing 20% P407 (w/w) and 0.10% C934P (w/w) was controlled by Fickian diffusion. Conclusion: The data obtained on these formulations indicate a potentially useful role in the endodontic treatment (pulp protection) and suggest they are worthy of clinical evaluation.
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