期刊
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
卷 34, 期 11, 页码 1168-1177出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/03639040801974295
关键词
Draize test; chick chorioallantoic membrane; formulation development; drug delivery; transport study; permeation
The use of animals in research has always been a debatable issue. Over the past few decades, efforts have been made to reduce, replace, and refine experiments for ethical use of experimental animals. The use of chick chorioallantoic membrane (CAM) was one of the proposed alternatives to the Draize rabbit ocular irritation test with several advantages including simplicity, rapidity, sensitivity, ease of performance, and cost-effectiveness. The recent use of CAM in the development of pharmaceuticals and testing models to mimic human tissue, including drug transport across CAM, will be discussed in this review.
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