4.7 Article

Enhanced hepatoprotective activity of andrographolide complexed with a biomaterial

期刊

DRUG DELIVERY
卷 22, 期 1, 页码 117-124

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TAYLOR & FRANCIS LTD
DOI: 10.3109/10717544.2013.871602

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Andrographolide; biomaterial; hepatoprotective; humic acid; solubility

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Context: Humic acid (HA), a natural organic matter is recently being investigated for pharmaceutical purposes. Andrographolide (AGP), a potent hepatoprotective, possesses low aqueous solubility which results in a low bioavailability after oral administration, inappropriate tissue localization and consequently poor therapeutic application. Objective: The present study investigates the complexation of AGP with HA to increase its solubility and hepatoprotective efficacy. Materials and methods: Complexes prepared by solvent evaporation in various weight ratios were characterized using differential scanning calorimetry, Fourier Transform InfraRed spectroscopy, X-ray diffraction, and scanning electron microscopy. Results and discussion: The complexed AGP demonstrated improved solubility, dissolution, and permeation across rat intestine. It also displayed better hepatoprotection against carbontetrachloride- induced liver toxicity than the free drug in rats. Conclusion: Complexation with HA is a valuable technique to improve solubility and bioavailability of pharmaceuticals.

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