期刊
DRUG DELIVERY
卷 18, 期 3, 页码 173-180出版社
INFORMA HEALTHCARE
DOI: 10.3109/10717544.2010.509363
关键词
Polymeric drug delivery systems; chitosan-collagen hydrogel incorporated with lysostaphin (CCHL); burn dressing; anti-Methicillin-Resistant Staphylococcus aureus; wound healing
资金
- Science and Technology Commission of Shanghai Municipal Govt. [08441900700]
Methicillin-resistant Staphylococcus aureus (MRSA) have become increasingly prevalent as nosocomial pathogens, especially in burn patients, which is the leading cause of their death. A drug delivery system of chitosan-collagen hydrogel incorporated with lysostaphin (CCHL) based on the lysostaphin gauze was developed for MRSA infected burn wounds. CCHL scaffold consisted of numerous interconnected sphericles and tubular bodies with an average diameter of 100-200 mu m, 20-60-fold swelling, high water retention capacity, and cell proliferation properties. The minimal inhibitory concentration of CCHL was 0.053 U/mL. By the second week after its application on MRSA infected third-degree burn wounds, no bacteria could be detected and the burn wounds had started healing. Therefore, CCHL should be studied further as a promising candidate of burn treatment dressing against MRSA infections for clinics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据