期刊
DRUG DELIVERY
卷 17, 期 2, 页码 77-82出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10717540903509001
关键词
Microspheres; alginate; chitosan; PLGA; modification
资金
- Zhejiang Provincial Natural Science Foundation of China [Y2080185]
To decrease the initial burst release of protein entrapped in PLGA microspheres, bovine serum albumin was entrapped into microspheres and a one-step modified method was evaluated. Low level of alginate was added into the internal aqueous phase with protein together; meanwhile calcium chloride and chitosan were put into the external, and all the other processes kept unvaried. After modification, the initial release was inhibited markedly, and the entrapment efficiency was increased slightly, while the particle size remained unaltered. An attracting result is that almost all the little pores at the surface of microspheres had been closed with the modification one under SEM.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据