期刊
DRUG DELIVERY
卷 17, 期 6, 页码 385-390出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10717541003762862
关键词
Retinoic acid; DMSO; hair follicle; epidermis; depilation; pORF-LacZ
资金
- State Key Basic Research and Development Plan [2010CB529900]
Simple and efficient gene transfer to the skin would facilitate many local and systemic gene therapy applications. This study reports a novel approach that allows expression of plasmid DNA in epidermis and hair follicle cells with dimethyl sulfoxide (DMSO) after pre-treatment with depilation and retinoic acid (RA) for the purposes of gene therapy. This study investigated the transdermal efficacy of gene to mouse skin when utilizing DMSO after RA pre-treatment. Retinoic acid pre-treatment can increase the efficiency of transfection. This finding indicates that one can more effectively and much less expensively make use of genes therapy to treat diseases of the hair and skin.
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