期刊
DRUG DELIVERY
卷 16, 期 6, 页码 331-340出版社
INFORMA HEALTHCARE
DOI: 10.1080/10717540903031126
关键词
Alginate; dexamethasone; polyelectrolyte coating
资金
- Department of Biotechnology, India
- National Institutes of Health [EB000739]
Alginate microspheres loaded with dexamethasone were prepared by the droplet generator technique. Important parameters affecting drug release, including initial drug content, the type of polyelectrolyte coating, and a combination of different ratios of coated and uncoated microspheres were investigated to achieve in vitro dexamethasone delivery with approximately zero order release kinetics, releasing up to 100% of entrapped drug within 1 month, wherein dexamethasone released at a steady rate of 4.83 mu g/day after an initial burst release period. These findings imply that these polyelectrolyte-coated alginate microspheres show promise as release systems to improve biocompatibility and prolong lifetime of implantable glucose sensors.
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