Cyclodextrin controlled release of poorly water-soluble drugs from hydrogels

The effect of 2-hydroxypropyl-o-cyclodextrin and gamma-cyclodextrin on the release of ibuprofen, ketoprofen and prednisolone was studied. Stability constants calculated for inclusion complexes show size dependence for complexes with both cyclodextrins. Hydrogels were prepared by ultraviolet irradiation and release of each model drug was studied. For drugs formulated using cyclodextrins an increase in the achievable concentration and in the release from hydrogels was obtained due to increased solubility, although the solubility of all gamma-cyclodextrin complexes was limited. The Load also was increased by adjusting pH for the acidic drugs and this exceeds the increase obtained wit gamma-cyclodextrin addition.