期刊
DRUG AND CHEMICAL TOXICOLOGY
卷 33, 期 3, 页码 325-328出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/01480540903449715
关键词
Tuberculosis; adverse effects; liver toxicity; antituberculosis treatment
资金
- KNCV Tuberculosis Foundation
Despite the important role of pyrazinannide in tuberculosis treatment, little is known about the mechanism of pyrazinamide-induced hepatotoxicity. We inhibited xanthine oxidase in HepG2 cells by using a nontoxic concentration of allopurinol, a well-known xanthine-oxidase inhibitor, This increased in vitro pyrazinamide toxicity in HepG2 cells, which suggests that the hydroxy metabolites of pyrazinamide are probably not fully responsible for pyrazinamide-induced toxicity, and that pyrazinoic acid and pyrazinamide are involved in pyrazinamide toxicity.
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