期刊
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
卷 151, 期 -, 页码 118-124出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2015.05.015
关键词
Andrographis echioides; Silver nanoparticles; Microscopic studies; MCF-7 cell line; Antibacterial
The present study reveals the efficiency of Andrographis echioides for green synthesis of silver nanopartides (AgNPs). The leaf aqueous extract of A. echioides was used for the synthesis of AgNPs and they were characterized by UV-visible, High Resonance Scanning Electron Microscope (HRSEM), Energy-Dispersive X-ray Spectroscopy (EDX), Atomic Force Microscope (AFM), X-ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) analysis. The toxicity of AgNPs was evaluated by using MTT assay. Our present study showed that biosynthesized AgNPs inhibited proliferation of human breast adenocarcinoma cancer cell line (MCF-7) with 31.5 mu g/mL at 24 h incubation. Results suggest that AgNPs may exert its anticancer activity on MCF-7 cell line by suppressing its growth. The silver nanoparticles was studied against Gram positive and Gram negative bacteria. The highest antibacterial activity was found against Escherichia coli (28 mm) and Staphylococcus aureus (23 mm) respectively. (C) 2015 Elsevier B.V. All rights reserved.
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