The cost-effectiveness of tailored, postal feedback on general practitioners' prescribing of pharmacotherapies for alcohol dependence

Aims: The aims of this study were to conduct a randomised controlled trial to evaluate the cost-effectiveness of tailored, postal feedback on general practitioners' (GPs) prescribing of acamprosate and naltrexone for alcohol dependence relative to current practice and its impact on alcohol dependence morbidity. Methods: Rural communities in New South Wales, Australia, were randomised into experimental (N = 10) and control (N = 10) communities. Tailored feedback on their prescribing of alcohol pharmacotherapies was mailed to GPs from the experimental communities (N = 115). Segmented regression analysis was used to examine within and between group changes in prescribing and alcohol dependence hospitalisation rates compared to the control communities. Incremental cost-effectiveness ratios (ICERs) were estimated per additional prescription of pharmacotherapies and per alcohol dependence hospitalisation(s) averted. Results: Post-intervention changes, relative to the control communities, in GPs' prescribing rate trends in the experimental communities significantly increased for acamprosate (beta = 0.24, 95% CI: 0.13-0.35, p < 0.001). and significantly decreased for naltrexone (beta = -0.12, 95% CI: -0.17 to -0.06) per quarter. Quarterly hospitalisation trend rates for alcohol dependence, as principal diagnosis, significantly decreased (beta = -0.07, 95% CI: -0.13 to -0.01, p < 0.05), compared to control communities. The median ICER per quarterly hospitalisation(s) averted due to intervention was Dominant (Dominant -$12,750). Conclusion: Postal, tailored feedback to GPs on their prescribing of acarnprosate and naltrexone for alcohol dependence was a cost-effective intervention, in rural communities of NSW, to increase the overall prescribing of pharmacotherapies with a plausible effect on incidence reduction of hospitalisations for alcohol dependence as principal diagnosis. (c) 2012 Elsevier Ireland Ltd. All rights reserved.