期刊
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
卷 148, 期 -, 页码 66-72出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2015.03.027
关键词
-
资金
- Molecular Medicine Ph.D. Program at the University of Milan
A series of furo[3,2-c]coumarin derivatives 1a-d were synthesized and evaluated for their antiproliferative activity against MCF-7 breast and HCT-15 colon cancer cell lines using Sulfo-rhodamine B (SRB) assay. Compounds 1b and 1d showed higher antiproliferative activity than 1a and 1c. UV-Vis spectroscopy was used for DNA and BSA-binding affinity of the compounds 1b and 1d and gave overall affinity constants of K1b-DNA = 8.1 x 10(3) M-1, K1d-DNA = 1.1 X 10(4) M-1, K1b-BSA = 5.1 x 10(4) M-1, and K1d-BSA = 7.6 x 10(4) M-1. Our findings could provide new evidence showing the relationship between the chemical structure and anticancer activity of these new coumarin analogs. (C) 2015 Elsevier B.V. All rights reserved.
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