期刊
DRUG AND ALCOHOL DEPENDENCE
卷 113, 期 1, 页码 21-28出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2010.06.017
关键词
Alcohol; Sensitivity; Alcoholism clinical course
资金
- NIAAA [AA005526]
- State of California for medical research on alcohol and substance abuse through the University of California, San Francisco
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA005526] Funding Source: NIH RePORTER
Background: Patterns of drinking and alcohol problems change with age. However, few studies use multiple data points and detailed history spanning early adulthood to middle age. This study reports such data from 373 men in the San Diego Prospective Study. Methods: Data were generated at baseline (T1) at similar to age 20, and through face-to-face followup interviews similar to every 5 years in >90% of these eligible Caucasian and relatively higher educated men. Subjects were placed into 4 groups regarding their course: 62.5% with no alcohol use disorder (AUD); 17.2% with AUD onset = age 30 and no recovery; and 13.7% with AUD onset 5 years before the 25-year followup. Results: On a univariate level, low level of response (LR) to alcohol, family history of AUDs, and higher Novelty Seeking at age similar to 20 predicted AUDs with onset before age 30 (mean age similar to 25), but among these only LR predicted later onset (mean age 38) as well. Additional predictors of AUDs included demography (lower education), and greater involvement with alcohol, drugs, and nicotine prior to T1. Sustained remission from AUDs among alcoholics was predicted by lower T1 and T10 drinking frequencies, and being separated or divorced at T10, along with a trend for higher Reward Dependence. Conclusion: These data indicate that information available in ages of the late teens to early twenties can help predict the future onset and course of AUDs, and underscore the importance of longitudinal studies in substance use disorders. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据