期刊
DRUG AND ALCOHOL DEPENDENCE
卷 111, 期 1-2, 页码 120-127出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2010.04.010
关键词
Cannabis; Marijuana; Withdrawal; Tolerance; Relapse
资金
- Intramural Research Program
- National Institutes of Health
- National Institute on Drug Abuse
- NIDA Residential Research Support Services [HHSN271200599091CADB]
Background: Cannabis withdrawal is not recognized in DSM-IV because of doubts about its clinical significance. Objectives: Assess the phenomenon of cannabis withdrawal and its relationship to relapse in non-treatment-seeking adults. Subjects: Convenience sample of 469 adult cannabis smokers who had made a quit attempt while not in a controlled environment. Methods: Subjects completed a 176-item Marijuana Quit Questionnaire collecting information on sociodemographic characteristics, cannabis use history, and their most difficult cannabis quit attempt. Results: 42.4% of subjects had experienced a lifetime withdrawal syndrome, of whom 70.4% reported using cannabis in response to withdrawal. During the index quit attempt, 95.5% of subjects reported >= 1 individual withdrawal symptom (mean [SD] 9.5 [6.1], median 9.0); 43.1% reported >= 10. Number of withdrawal symptoms was significantly associated with greater frequency and amount of cannabis use, but symptoms occurred even in those using less than weekly. Symptoms were usually of >= moderate intensity and often prompted actions to relieve them. Alcohol (41.5%) and tobacco (48.2%) were used more often than cannabis (33.3%) for this purpose. There was little change during withdrawal in use of other legal or illegal substances. Conclusions: Cannabis withdrawal is a common syndrome among adults not seeking treatment. The intention to relieve withdrawal symptoms can drive relapse during quit attempts, giving cannabis withdrawal clinical significance as a target of treatment. Published by Elsevier Ireland Ltd.
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