期刊
DRUG AND ALCOHOL DEPENDENCE
卷 104, 期 -, 页码 S94-S99出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2008.11.012
关键词
Nicotine dependence; Smoking cessation; Sex; Pharmacogenetic
资金
- National Cancer Institute [R01 CA95678, R01 CA126969]
- National Institute of Drug Abuse [P50 CA/DA84718]
- Commonwealth of Pennsylvania [4100027297]
- American Cancer Society [RSGPB-05-240-01-CPPB]
- NATIONAL CANCER INSTITUTE [R01CA095678, P50CA084718, R01CA126969] Funding Source: NIH RePORTER
Approximately one-quarter of smokers who use treatments for nicotine dependence are able to achieve cessation. However, there is evidence that women do not respond as well to nicotine replacement therapy (NRT) and, perhaps, to bupropion, compared to men. In this contribution to the Special Issue of Drug and Alcohol Dependence concerning Women and Smoking, we begin with a brief overview of data supporting the role of sex in influencing response to NRT and bupropion. Next, we summarize the results of pharmacogenetic smoking cessation clinical trials which assessed sex as a moderator as well. A relatively small number of pharmacogenetic studies of nicotine dependence treatments have been conducted and five studies reported sex effects in these trials. Of these trials, sex moderated the association of genetic variation in drug pharmacokinetics or pharmacodynamics and treatment response. We conclude this paper with a summary and a brief discussion of the major caveats of this literature and priorities for future research. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据