期刊
DOSE-RESPONSE
卷 8, 期 1, 页码 16-21出版社
INT DOSE-RESPONSE SOC
DOI: 10.2203/dose-response.09-014.Vaiserman
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Hormesis is a common phenomenon in a number of biomedical areas. However, the basic nature of this phenomenon remains largely unknown. Therefore, significant uncertainty is inevitable in attempts to apply hormesis as a pro-health and anti-aging tool. Evidence supporting that hormetic-like effects may be the result of a generalized whole-organism adaptive epigenetic response is reviewed. Specific hormesis-inducing interventions during development would allow to achieve an optimal balance between activation and repression of various genes and thus to prevent age-related degenerative diseases and slow aging. The reasons that oscillating temperature mild stress could potentially be used for human application are discussed.
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