Quinazoline-benzimidazole hybrid as dual optical sensor for cyanide and Pb2+ ions and Aurora kinase inhibitor

Compounds 1 and 2 exhibited selective fluorescence response toward Pb2+ over the other metal ions like Zn2+, Co2+, Ca2+, K+, Ni2+, Mn2+, Fe2+, Hg2+, Na+ etc. Compound 1 behaved as cyanide selective chromofluorescent sensor amongst other anions like F-, Cl-, Br-, I-, AcO-, H2PO4-, HSO4- etc. The binding properties of compounds 1 and 2 with cyanide and Pb2+ were investigated via UV-vis, fluorescence spectroscopy, H-1 NMR titration experiment and DFT calculations. Compound 1 has been used to estimate CN- ion (2-500 mu M) and compound 2 used to estimate Pb2+ ion (0.05-1500 mu M) ratiometrically. Compounds 1 and 2 have also been used as Aurora kinase inhibitors with IC50 values of 7.50 mu M and 0.53 mu M, respectively. (C) 2015 Elsevier B.V. All rights reserved.