期刊
DOCUMENTA OPHTHALMOLOGICA
卷 119, 期 3, 页码 217-224出版社
SPRINGER
DOI: 10.1007/s10633-009-9204-7
关键词
Psychophysics; Treatment trials; Retina; LCA; RP; CRD
资金
- Foundation Fighting Blindness
To determine whether the Diagnosys full-field stimulus threshold (D-FST) is a valid, sensitive and repeatable psychophysical method of measuring and following visual function in low-vision subjects. Fifty-three affected eyes of 42 subjects with severe retinal degenerative diseases (RDDs) were tested with achromatic stimuli on the D-FST. Included were subjects who were either unable to perform a static perimetric field or had non-detectable or sub-microvolt electroretinograms (ERGs). A subset of 21 eyes of 17 subjects was tested on both the D-FST and the FST2, a previous established full-field threshold test. Seven eyes of 7 normal control subjects were tested on both the D-FST and the FST2. Results for the two methods were compared with the Bland-Altman test. On the D-FST, a threshold could successfully be determined for 13 of 14 eyes with light perception (LP) only (median 0.9 +/- A 1.4 log cd/m(2)), and all eyes determined to be counting fingers (CF; median 0.3 +/- A 1.8 log cd/m(2)). The median full-field threshold for the normal controls was -4.3 +/- A 0.6 log cd/m(2) on the D-FST and -4.8 +/- A 0.9 log cd/m(2) on the FST2. The D-FST offers a commercially available method with a robust psychophysical algorithm and is a useful tool for following visual function in low vision subjects.
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