期刊
DNA RESEARCH
卷 15, 期 6, 页码 367-374出版社
OXFORD UNIV PRESS
DOI: 10.1093/dnares/dsn025
关键词
singular value decomposition; gene expression; gene correlation; Arabidopsis
资金
- MEXT
- BIRD, Japan Science and Technology Agency
Gene co-expression analysis has been widely used in recent years for predicting unknown gene function and its regulatory mechanisms. The predictive accuracy depends on the quality and the diversity of data set used. In this report, we applied singular value decomposition (SVD) to array experiments in public databases to find that co-expression linkage could be estimated by a much smaller number of array data. Correlations of co-expressed gene were assessed using two regulatory mechanisms (feedback loop of the fundamental circadian clock and a global transcription factor Myb28), as well as metabolic pathways in the AraCyc database. Our conclusion is that a smaller number of informative arrays across tissues can suffice to reproduce comparable results with a state-of-the-art co-expression software tool. In our SVD analysis on Arabidopsis data set, array experiments that contributed most as the principal components included stamen development, germinating seed and stress responses on leaf.
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