期刊
DNA REPAIR
卷 17, 期 -, 页码 21-29出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2014.02.020
关键词
DNA double strand breaks; Non-homologous end-joining; Ku70/80; DNA-PKcs; XRCC4; DNA ligase IV; XLF
资金
- National Institutes of Health grants [CA162804, CA92584, CA13499, CA166677]
- Cancer Prevention and Research Institute of Texas [RP110465]
DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB repair pathway in humans is non-homologous end-joining (NHEJ). In the simplest sense, NHEJ mediates the direct re-ligation of the broken DNA molecule. However, NHEJ is a complex and versatile process that can repair DSBs with a variety of damages and ends via the utilization of a significant number of proteins. In this review we will describe the important factors and mechanisms modulating NHEJ with emphasis given to the versatility of this repair process and the DNA-PR complex. (C) 2014 Elsevier B.V. All rights reserved.
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