期刊
DNA REPAIR
卷 17, 期 -, 页码 74-80出版社
ELSEVIER
DOI: 10.1016/j.dnarep.2014.02.006
关键词
Double-strand break repair, Lymphoma; Chromosomal rearrangements V(D)J; recombination, Class switch recombination
资金
- NCI NIH HHS [R01 CA100504, R37 CA051105] Funding Source: Medline
Artemis and PALF (also called APLF) appear to be among the primary nucleases involved in non-homologous end joining (NHEJ) and responsible for most nucleolytic end processing in NHEJ. About 60% of NHEJ events show an alignment of the DNA ends that use 1 or 2 bp of microhomology (MH) between the two DNA termini. Thus, MH is a common feature of NHEJ. For most naturally occurring human chromosomal deletions (e.g., after oxidative damage or radiation) and translocations, such as those seen in human neoplasms and as well as inherited chromosomal structural variations, MH usage occurs at a frequency that is typical of NHEJ, and does not suggest major involvement of alternative pathways that require more extensive MH. Though we mainly focus on human NHEJ at double-strand breaks, comparison on these points to other eukaryotes, primarily S. cerevisiae, is informative. (C) 2014 Elsevier B.V. All rights reserved.
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