期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 104, 期 3, 页码 1099-1107出版社
WILEY-BLACKWELL
DOI: 10.1002/jps.24305
关键词
biomaterials; extrusion; polymeric drug delivery systems; poly(lactic; glycolic) acid (PLGA or PLA); controlled release; anti-infectives; spectroscopy; polymers; microscopy; drug delivery systems
资金
- Danish Agency for Science and Technology and Innovation (DanCARD) [06-097075]
- Danish Council for Independent Research (DFF), Technology and Production Sciences (FTP) [12-126515/0602-02670B]
- Lundbeck Foundation [R108-A10760]
- Innovation Fund Denmark [041-2010-3]
The aim of the present work was to investigate the potential of three-dimensional (3D) printing as a manufacturing method for products intended for personalized treatments by exploring the production of novel polylactide-based feedstock materials for 3D printing purposes. Nitrofurantoin (NF) and hydroxyapatite (HA) were successfully mixed and extruded with up to 30% drug load with and without addition of 5% HA in polylactide strands, which were subsequently 3D-printed into model disc geometries (10 x 2 mm). X-ray powder diffraction analysis showed that NF maintained its anhydrate solid form during the processing. Release of NF from the disks was dependent on the drug loading in a concentration-dependent manner as a higher level of released drug was observed from disks with higher drug loads. Disks with 30% drug loading were able to prevent surface-associated and planktonic growth of Staphylococcus aureus over a period of 7 days. At 10% drug loading, the disks did not inhibit planktonic growth, but still inhibited surface-associated growth. Elemental analysis indicated the presence of microdomains of solid drug supporting the observed slow and partial drug release. This work demonstrates the potential of custom-made, drug-loaded feedstock materials for 3D printing of pharmaceutical products for controlled release. (c) 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:1099-1107, 2015
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