Posttranslational modifications of repair factors and histones in the cellular response to stalled replication forks

DNA damage during replication requires an integration of checkpoint response with replication itself and distinct repair pathways, such as replication pausing. recombination and translesion synthesis. Here we focus on recent advances in our understanding of how protein posttranslational modifications contribute to the maintenance of fork integrity. in particular, we examine the role of histone modifications and chromatin remodeling complexes in this process. (C) 2009 Elsevier B.V. All rights reserved.