期刊
DNA REPAIR
卷 8, 期 4, 页码 536-543出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2009.01.011
关键词
Ubiquitin; Cullin-RING ligase; Nucleotide excision repair
资金
- NIH/NCI [CA098219]
- Leukemia and Lymphoma Society
- Irma T. Hirschl Trust
- STARR Cancer Consortium
Eukaryotic cells repair ultraviolet light (UV)- and chemical carcinogen-induced DNA strand-distorting damage through the nucleotide excision repair (NER) pathway. Concurrent activation of the DNA damage checkpoints is also required to arrest the cell cycle and allow time for NER action. Recent studies uncovered critical roles for ubiquitin-mediated post-translational modifications in controlling both NER and checkpoint functions. In this review, we will discuss recent progress in delineating the roles of cullin-RING E3 ubiquitin ligases in orchestrating the cellular DNA damage response through ubiquitination of NER factors, histones, and checkpoint effectors. (C) 2009 Elsevier B.V. All rights reserved.
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