XPD structure reveals its secrets

The XPD Protein is central to our understanding of the relationship between NER deficiencies and human disorders. Three recent papers report the crystal structures of XPD from archaea. Apart from anticipated helicase domains the structures reveal a 4FeS cluster and novel Arch domain. The structures help our understanding of genotype-phenotype relationships in the XPD gene. (C) 2008 Elsevier B.V All rights reserved.