期刊
DNA REPAIR
卷 7, 期 7, 页码 1121-1134出版社
ELSEVIER
DOI: 10.1016/j.dnarep.2008.03.013
关键词
mismatch repair; MSH2; MSH3; MSH6; DNA repair; microsatellite instability; trinucleotide repeats; CAG repeats; CTG repeats; base excision repair; break repair; OGG1; Huntington's disease; myotonic dystrophy; cisplatin lesions; DNA lesions; chemical lesions
资金
- NCI NIH HHS [P01 CA092584, P01 CA092584-10] Funding Source: Medline
- NIGMS NIH HHS [R01 GM066359-06, R01 GM066359-04, R01 GM066359-02, R01 GM066359-05A1, R01 GM066359, R01 GM066359-01A2, R01 GM066359-06S1, R01 GM066359-07, R01 GM066359-08, R01 GM066359-05A1S1, GM066359, R01 GM066359-03] Funding Source: Medline
- NINDS NIH HHS [R01 NS060115-02S1, R01 NS040738-09, R01 NS040738-04S1, R01 NS040738-05, R01 NS040738-01, R01 NS062384, R01 NS040738-08, R01 NS040738-03, R01 NS060115-04, R01 NS040738-04, NS40738, R01 NS040738-07, NS060115, R01 NS060115-02, R01 NS040738-06, R01 NS040738-02, R01 NS060115-01, R01 NS040738, R01 NS040738-02S1, R01 NS060115-03, R01 NS060115] Funding Source: Medline
Mammalian cells have evolved sophisticated DNA repair systems to correct mispaired or damaged bases and extrahelical loops. Emerging evidence suggests that, in some cases, the normal DNA repair machinery is hijacked to become a causative factor in mutation and disease, rather than act as a safeguard of genomic integrity. In this review, we consider two cases in which active MMR leads to mutation or to cell death. There may be similar mechanisms by which uncoupling of normal MMR recognition from downstream repair allows triplet expansions underlying human neurodegenerative disease, or cell death in response to chemical lesion. (C) 2008 Elsevier B.V. All rights reserved.
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