期刊
DNA AND CELL BIOLOGY
卷 33, 期 11, 页码 802-806出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2014.2527
关键词
-
资金
- Nanjing Science and Technology Development Program [201303039]
The transforming growth factor-beta (TGF-beta) signaling pathway plays critical roles in the development of various diseases. The current study investigated whether TGF-beta was involved in the pathogenesis of osteosarcoma from the genetic polymorphism perspective and serum level perspective. We first examined two TGF-beta 1 polymorphisms, rs1800469C/T and rs1800470T/C, in 202 osteosarcoma patients and 216 healthy controls. Data revealed that the prevalence of rs1800470TT genotype and T allele was significantly elevated in patients than in controls (odds ratio [OR]=2.28, 95% confidence interval [CI]: 1.30-3.98, p<0.001, and OR=1.49, 95% CI: 1.14-1.96, p<0.001). Function analyses showed that healthy controls carrying rs1800470TT genotype had a significantly higher serum level of TGF-beta than those carrying the rs1800470CC genotype (191.1 +/- 15.7 pg/mL vs. 129.4 +/- 10.9 pg/mL, p=0.003). We then compared the serum level of TGF-beta between osteosarcoma patients and healthy controls. Results demonstrated a significantly increased serum level of TGF-beta in patients than in controls. Further analyses identified that patients with metastasis had augmented levels of serum TGF-beta than those without metastasis. These data indicate that TGF-beta may be closely involved in the pathogenesis of osteosarcoma.
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