期刊
DNA AND CELL BIOLOGY
卷 31, 期 5, 页码 766-771出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2011.1427
关键词
-
资金
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0631]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
The Toll-like receptors (TLRs) are important for the innate immune system by recognizing pathogen-associated molecular patterns expressed in infectious agents. E6 and E7 protein from HPV16 suppress the host immune response by regulating the TLR9 transcript. Therefore, we hypothesized that a single nucleotide polymorphism in TLR9 may contribute to cervical cancer. We genotyped TLR9 -1486T/C (rs187084) in a case-control study of 712 cervical cancer cases and 717 cancer-free controls in Chinese women. Logistic regression analyses showed that the rs187084 heterozygote TC was associated with a significantly increased risk of cervical cancer (adjusted OR = 1.28, 95% CI = 1.01-1.62), compared with the TT genotype. Although the variant homozygote was associated with a nonsignificantly increased cervical cancer risk, the TC/CC genotypes contributed to the risk of cervical cancer in the dominant genetic model (adjusted OR = 1.24, 95% CI = 1.01-1.53). The findings indicate that TLR9 -1486T/C (rs187084) may contribute to cervical cancer carcinogenesis.
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