期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 113, 期 -, 页码 108-120出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2014.12.017
关键词
Metabolomics; Laboratory diagnostics; Biological samples; Biomarkers; Analytical techniques
资金
- Ministry of Science and Higher Education of the Republic of Poland
- National Centre of Science [2012/05/B/NZ7/03293]
Metabolomics is an emerging approach in a systems biology field. Due to continuous development in advanced analytical techniques and in bioinformatics, metabolomics has been extensively applied as a novel, holistic diagnostic tool in clinical and biomedical studies. Metabolome's measurement, as a chemical reflection of a current phenotype of a particular biological system, is nowadays frequently implemented to understand pathophysiological processes involved in disease progression as well as to search for new diagnostic or prognostic biomarkers of various organism's disorders. In this review, we discussed the research strategies and analytical platforms commonly applied in the metabolomics studies. The applications of the metabolomics in laboratory diagnostics in the last 5 years were also reviewed according to the type of biological sample used in the metabolome's analysis. We also discussed some limitations and further improvements which should be considered taking in mind potential applications of metabolomic research and practice. (C) 2014 Elsevier B.V. All rights reserved.
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