期刊
DISEASES OF THE ESOPHAGUS
卷 26, 期 4, 页码 356-358出版社
WILEY-BLACKWELL
DOI: 10.1111/dote.12055
关键词
Bmp; EA; TEF; foregut separation; Sox2
资金
- NIH [K99/R00, DK082650]
- March of Dimes Basil O'Connor Starter Scholar Research Award
Foregut separation involves dynamic changes in the activities of signaling pathways and transcription factors. Recent mouse genetic studies demonstrate that some of these pathways interact with each other to form a complex network, leading to a unique dorsal-ventral patterning in the early foregut. In this review, it is discussed how this unique dorsal-ventral patterning is set prior to the foregut separation and how disruption of this patterning affects the separation process. Roles of downstream targets of these pathways in regulating separation at cellular and molecular levels would be discussed further. Understanding the mechanism of normal separation process will provide insights into the pathobiology of a relatively common birth defect, esophageal atresia with/without tracheoesophageal fistula.
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