期刊
DISEASE MODELS & MECHANISMS
卷 5, 期 1, 页码 38-47出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dmm.007138
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资金
- UK Medical Research Council (MRC) [G0701932]
- MRC Centre [G0700091]
- National Institutes of Health (NIH) NHLBI [K08 HL004233, 1R21HD060310]
- Dana Foundation
- William-Lawrence Blanche Hughes Foundation
- Alex's Lemonade Stand Foundation
- Huntsman Cancer Foundation
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R21HD060310] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K08HL004233] Funding Source: NIH RePORTER
- MRC [G0701932] Funding Source: UKRI
- Medical Research Council [G0701932, G0700091B] Funding Source: researchfish
Since its first splash 30 years ago, the use of the zebrafish model has been extended from a tool for genetic dissection of early vertebrate development to the functional interrogation of organogenesis and disease processes such as infection and cancer. In particular, there is recent and growing attention in the scientific community directed at the immune systems of zebrafish. This development is based on the ability to image cell movements and organogenesis in an entire vertebrate organism, complemented by increasing recognition that zebrafish and vertebrate immunity have many aspects in common. Here, we review zebrafish immunity with a particular focus on recent studies that exploit the unique genetic and in vivo imaging advantages available for this organism. These unique advantages are driving forward our study of vertebrate immunity in general, with important consequences for the understanding of mammalian immune function and its role in disease pathogenesis.
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