期刊
DISEASE MODELS & MECHANISMS
卷 3, 期 11-12, 页码 678-688出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dmm.002915
关键词
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资金
- NIH
- March of Dimes Foundation
- American Heart Association
- University of California Pediatric Neuropathology Consortium
Newborn neurological injuries are the leading cause of intellectual and motor disabilities that are associated with cerebral palsy. Cerebral white matter injury is a common feature in hypoxic-ischemic encephalopathy (HIE), which affects fullterm infants, and in periventricular leukomalacia (PVL), which affects preterm infants. This article discusses recent efforts to model neonatal white matter injury using mammalian systems. We emphasize that a comprehensive understanding of oligodendrocyte development and physiology is crucial for obtaining new insights into the pathobiology of HIE and PVL as well as for the generation of more sophisticated and faithful animal models.
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