期刊
DISEASE MARKERS
卷 2014, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2014/367157
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资金
- National Science Council (NSC) [100-2314-B-040-012]
- Chung Shan Medical University Hospital [CSH-2012-C-016]
The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1). Multivariate logistic regression analysis also showed that patients with high expression levels of the six target miRNAs had an approximately 7.202-fold risk of CHC compared with those with low expression levels of the target miRNAs. We concluded that the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC.
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