期刊
DISEASE MARKERS
卷 2013, 期 -, 页码 97-103出版社
HINDAWI LTD
DOI: 10.1155/2013/816189
关键词
-
类别
资金
- National Natural Science Foundation of China [30770850, 81201335]
- Scientific and Technological Ministry of Hubei province, China [2007ABB024, 2009CDA079]
Paraoxonase-1 (PON1), a high-density-lipoprotein-(HDL-) associated enzyme, has the potential to protect against atherogenesis. We examine the relationships between plasma PON1 activity and the progression of atherosclerosis aswell as coronary artery disease (CAD). Fasting blood samples were collected from female apolipoprotein E-deficient (apoE(-/-)) mice and 149 patients undergoing coronary angiography for the biochemical parameters measurement. The severity of CAD was defined using angiographic Gensini score (GSS). Compared to 3-month-old apoE(-/-) mice, aged mice had significantly lower PON1 activity, which is negatively correlated with the size of atherosclerotic lesion and plasma interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) levels. In study patients, PON1 activity was correlated with age, sex, and HDL-cholesterol, apolipoprotein AI, and high-sensitivity C-reactive protein (hs-CRP) levels and was significantly lower in CAD group than that in non-CAD control group. Interestingly, PON1 activity in severe CAD group (GSS > 40) was further significantly reduced compared to those in mild and moderate subgroups (GSS <= 40) (P<0.01). There is a significant correlation between PON1 activity and the severity of CAD as assessed by GSS (r = 0.393, p<0.001). PON1 activity may be a potential biomarker for the severity of CAD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据