期刊
DISEASE MARKERS
卷 27, 期 1, 页码 37-44出版社
HINDAWI LTD
DOI: 10.1155/2009/978157
关键词
Protein arginine N-methyltransferase type I 1 (PRMT1); dimethylarginine dimethylaminohydrolase 2 (DDAH2); nitric oxide synthase 3 (NOS3); cardiovascular risk; asymmetric dimethylarginine (ADMA); atherosclerosis
类别
资金
- Linea Especial about Nutrition, Obesity and Health [LE/97]
- Health Department of the Government of Navarra [22/2007]
- The Capes Foundation of the Ministry of Education of Brazil [375605-0]
- ADA fellowships scheme of the University of Navarra
The purpose of this study was to evaluate whether the mRNA expression profiles of three genes (PRMT1, DDAH2 and NOS3) are related to ADMA metabolism and signalling, and the potential relationships with anthropometrical, biochemical, lifestyle and inflammatory indicators in healthy young adults. An emphasis on the putative effect of different mRNA expression on cardiovascular risk-related features was paid. Anthropometrical measurements as well as lifestyle features were analyzed in 120 healthy young adults. Fasting blood samples were collected for the measurement of glucose and lipid profiles as well as the concentrations of selected inflammatory markers. Profiles of mRNA expression were assessed for PRMT1, DDAH2 and NOS3 genes from peripheral blood mononuclear cells. Regarding inflammatory biomarkers, DDAH2 was inversely associated with IL-6 and TNF-alpha. Moreover, subjects in the highest quintile of DDAH2 mRNA expression showed a reduced risk to have higher values of waist circumference, and to be more prone to show higher values of HDL-c. Interestingly, DDAH2 gene expression seemed to be related with some anthropometrical, biochemical, lifestyle and inflammatory indicators linked to cardiovascular risk in apparently healthy young adults, emerging as a potential disease marker.
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