期刊
JOURNAL OF PEPTIDE SCIENCE
卷 22, 期 1, 页码 28-35出版社
WILEY-BLACKWELL
DOI: 10.1002/psc.2835
关键词
antimicrobial peptide; polybia-CP; candidiasis; antifungal; ROS production
资金
- National Natural Science Foundation of China [81573265, 20932003, 91213302, 21272102, 31200584, 21272108, 31401602]
- Key National S&T Program Major New Drug Development' of the Ministry of Science and Technology [2012ZX09504001-003]
- Research Fund for the Doctoral Program of Higher Education of China [20120211120045]
- Fundamental Research Funds for the Central Universities [lzujbky-2015-155, lzujbky-2015-279]
The incidence of life-threatening invasive fungal infections increased significantly in recent years. However, the antifungal therapeutic options are very limited. Antimicrobial peptides are a class of potential lead chemical for the development of novel antifungal agents. Antimicrobial peptide polybia-CP was purified from the venom of the social wasp Polybia paulista. In this study, we synthesized polybia-CP and determined its antifungal effects against a series of Candidian species. Our results showed that polybia-CP has potent antifungal activity and fungicidal activity against the tested fungal cells with a proposed membrane-active action mode. In addition, polybia-CP could induce the increase of cellular reactive oxygen species production, which would attribute to its antifungal activity. In conclusion, the present study suggests that polybia-CP has potential as an antifungal agent or may offer a new strategy for antifungal therapeutic option. Copyright (c) 2015 European Peptide Society and John Wiley & Sons, Ltd.
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