Outcome of distal pancreatectomy for pancreatic adenocarcinoma

Objectives: To determine the outcome of patients undergoing distal pancreatectomy for pancreatic adenocarcinoma. Methods: A retrospective review of 39 patients undergoing distal pancreatectomy for adenocarcinoma. Results: Thirty patients underwent surgery for ductal adenocarcinoma, 5 for malignant intraductal papillary mucinous neoplasm and 4 for mucinous cystadenocarcinoma. Malignant cystic neoplasms were significantly less likely to demonstrate perineural invasion, more likely to be well-differentiated, of lower T stage and of lower AJCC staging compared to ductal adenocarcinoma. These had a longer median disease-specific survival ( 42 ( 3 - 144) vs. 15 ( 14 - 16) months, p = 0.002). Eight patients underwent extended resections. These were associated with longer operating times compared to standard resections but there was no difference in surgical morbidity or mortality, blood transfusions, length of hospitalization or long-term survival. Univariate analysis demonstrated that R2 resection, size >30 mm, lymph node involvement, need for perioperative blood transfusion, serum albumin <40 g/l and platelet count <200/mu l were predictors of survival for ductal adenocarcinoma. Conclusions: Malignant cystic neoplasms have less aggressive behavior and more favorable outcome compared to ductal adenocarcinoma. R2 resection, larger tumor size, lymph node involvement, perioperative transfusion, decreased serum albumin and low platelet count are factors associated with decreased survival in patients with ductal adenocarcinoma undergoing distal pancreatectomy. Copyright (C) 2008 S. Karger AG, Basel.