期刊
JOURNAL OF PEDIATRICS
卷 167, 期 1, 页码 52-U410出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2015.02.052
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资金
- Swiss National Science Foundation [3200B0-108176/1]
- Roche Foundation for Anemia Research
Objective To investigate the safety and short term outcome of high dose recombinant human erythropoietin (rhEpo) given shortly after birth and subsequently over the first 2 days for neuroprotection to very preterm infants. Study design Randomized, double masked phase II trial. Preterm infants (gestational age 26 0/7-31 6/7 weeks) were given rhEpo (n(t) = 229; 3000 U/kg body weight) or NaCl 0.9% (n(c) = 214) intravenously at 3, 12-18, and 3642 hours after birth. Results There were no relevant differences between the groups for short-term outcomes such as mortality, retinopathy of prematurity, intraventricular hemorrhage, sepsis, necrotizing enterocolitis, and bronchopulmonary dysplasia. At day 7-10, we found significantly higher hematocrit values, reticulocyte, and white blood cell counts, and a lower platelet count in the rhEpo group. Conclusions Early high-dose rhEpo administration to very premature infants is safe and causes no excess in mortality or major adverse events.
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