期刊
DIGESTIVE DISEASES AND SCIENCES
卷 54, 期 11, 页码 2312-2317出版社
SPRINGER
DOI: 10.1007/s10620-009-0951-9
关键词
Proton pump inhibitors; Inflammation; Anti-inflammatory agents; Anti-oxidants; Oxidative stress; Eosinophilic esophagitis
资金
- Office of Medical Research, Department of Veterans Affairs
- National Institutes of Health [R01-CA134571, R01-DK63621]
Proton pump inhibitors (PPIs) are potent blockers of gastric acid secretion, and are widely regarded as the agents of choice for the treatment of acid-peptic disorders. For patients with upper gastrointestinal symptoms of uncertain etiology, improvement with PPI therapy is considered prima facie evidence of a pathogenetic role for acid-peptic disease. In addition to anti-secretory effects, however, PPIs have been found to have anti-oxidant properties and direct effects on neutrophils, monocytes, endothelial, and epithelial cells that might prevent inflammation. Those anti-inflammatory effects of the PPIs might influence a variety of inflammatory disorders, both peptic and non-peptic, within and outside of the gastrointestinal tract. The purpose of this report is to review the mechanisms whereby PPIs might exert anti-inflammatory effects exclusive of gastric acid inhibition, to discuss the clinical implications of those effects, and to emphasize that a clinical response to PPIs should not be construed as proof for an underlying acid-peptic disorder.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据