期刊
DIGESTIVE AND LIVER DISEASE
卷 44, 期 9, 页码 729-735出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.dld.2012.03.008
关键词
Coeliac disease; Cognitive performance; Psychometric tests
Introduction: Retrospective studies and case reports suggest an association between coeliac disease and impaired cognitive function. Aim: To evaluate functional and cognitive performances in coeliac disease vs. control patients older than 65 years. Method: Eighteen coeliac disease patients (75 4 years, group A) on gluten free diet since 5.5 +/- 3 years and 18 age-sex matched controls (76 4 years, group B) were studied using a battery of neuropsychological tests. Results of functional and cognitive tests are expressed as row scores and as equivalent scores by relating raw scores to reference rank categories. Results: Barthel Index of functional performance was similar in the 2 groups. Raw score was significantly lower in coeliac disease than controls for Mini Mental Test Examination (p = 0.02), Trail Making Test (p = 0.001), Semantic Fluency (p = 0.03), Digit Symbol Test (p = 0.007), Ideo-motor apraxia (p < 0.001) and Bucco-facial apraxia (p < 0.002). Equivalent score was also lower in coeliac disease than controls for Semantic memory (p < 0.01) and for Ideo-motor apraxia (p = 0.007). Conclusion: Cognitive performance is worse in elderly coeliac disease than control patients, despite prolonged gluten avoidance in coeliacs. Awareness on the increasing phenomenon of late-onset coeliac disease is important to minimize diagnostic delay and prolonged exposure to gluten that may adversely and irreversibly affect cognitive function. (C) 2012 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据