期刊
JOURNAL OF PEDIATRICS
卷 167, 期 2, 页码 274-+出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2015.04.047
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类别
资金
- Alberta Innovates, Health Solutions Summer Studentship
- Molly Towell Perinatal Research Foundation Fellowship
- Heart and Stroke Foundation/University of Alberta Professorship of Neonatal Resuscitation
- Heart and Stroke Foundation of Canada Research Scholarship
Objective To examine the temporal course of lung aeration at birth in preterm infants <33 weeks gestation. Study design The research team attended deliveries of preterm infants <33 weeks gestation at the Royal Alexandra Hospital. Infants who received only continuous positive airway pressure were eligible for inclusion. A combined carbon dioxide (CO2) and flow-sensor was placed between the mask and the ventilation device. To analyze lung aeration patterns during spontaneous breathing, tidal volume (V-T), and exhaled CO2 (ECO2) were recorded for the first 100 breaths. Results Thirty preterm infants were included with a total of 1512 breaths with mask leak <30%. Mean (SD) gestational age and birth weight was 30 (1) weeks and 1478 (430) g. Initial V-T and ECO2 for the first 30 breaths was 5-6 mL/kg and 15-22 mm Hg, respectively. V-T and ECO2 increased over the next 20 breaths to 7-8 mL/kg and 25-32 mm Hg, respectively. For the remaining observation period VT decreased to 4-6 mL/kg and ECO2 continued to increase to 35-37 mm Hg. Conclusions Preterm infants begin taking deeper breaths approximately 30 breaths after initiating spontaneous breathing to inflate their lungs. Concurrent CO2 removal rises as alveoli are recruited. Lung aeration occurs in 2 phases: initially, large volume breaths with poor alveolar aeration followed by smaller breaths with elimination of CO2 as a consequence of adequate aeration.
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