期刊
DIGESTIVE AND LIVER DISEASE
卷 42, 期 9, 页码 611-615出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.dld.2010.02.002
关键词
Carcinogenesis; Colorectal neoplasm; Microsatellite instability; Tumour location
Background: Microsatellite unstable CRC is associated with female gender, large tumours, and poor differentiation. However, there are few reports about the characteristics and differences of sporadic microsatellite unstable CRC based on tumour location. Aims: Site-specific heterogeneity of sporadic microsatellite unstable colorectal cancer (CRC) based on location was elucidated. Methods: We enrolled 164 CRC patients with high-frequency microsatellite instability (MSI-H) from the prospective database of 2686 consecutive CRC patients who underwent surgical resection. We analysed microsatellite instability (MSI) and expression of mismatch repair (MMR) proteins (MLH1. MSH2, and MSH6). Results: Among the 164 MSI-H CRC, 105 (64.0%) were located in the proximal colon and 59 (36.0%) were located in the distal colon. The proximal MSI-H CRC was predominantly in female (p = 0.014), had a more aggressive differentiation (p = 0.001), was of advanced stage (p = 0.035), and had a frequent loss of MLH1 expression (p = 0.005) compared to the distal MSI-H CRC. Conclusion: There were different clinicopathologic characteristics and MMR protein expression between proximal and distal MSI-H CRC. These findings suggest that the underlying carcinogenic pathway or molecular background differs according to location, despite being microsatellite unstable CRC. (C) 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据