期刊
DIFFERENTIATION
卷 84, 期 1, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.diff.2012.04.003
关键词
Cardiac cushion formation; Mouse; Chicken; BMP; TGFbeta; EMT
资金
- Dutch Heart Foundation
- Netherlands Institute for Regenerative Medicine
- BioMedical Materials institute
Cardiac cushion formation is crucial for both valvular and septal development. Disruption in this process can lead to valvular and septal malformations, which constitute the largest part of congenital heart defects. One of the signaling pathways that is important for cushion formation is the TGF beta superfamily. The involvement of TGF beta and BMP signaling pathways in cardiac cushion formation has been intensively studied using chicken in vitro explant assays and in genetically modified mice. In this review, we will summarize and discuss the role of TGF beta and BMP signaling components in cardiac cushion formation. (C) 2012 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据