期刊
DIFFERENTIATION
卷 79, 期 1, 页码 15-20出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.diff.2009.09.002
关键词
Mesenchymal stromal cells; Nerve growth factors; Oligodendrocyte progenitor cells; Transdifferentiation; Wharton's jelly
资金
- Natural Science Foundation of China (NSFC) [U0632008, 30772232, 30801184]
- Foundations for Key Sci-Tech Research Projects of Guangdong Province [2006Z3- E522, 05/06-7005206, 05/06-7005213, 258- 2008A030201019]
Human Wharton's jelly-derived mesenchymal stromal cells (hWJ-MSCs) are capable of differentiating into neural and astroglia-like cell types. However, a reliable means of inducing the selective differentiation of hWJ-MSCs into oligodendrocyte progenitor cells (OPCs) in vitro has not yet been established. In this study, the OPC-like differentiation of hWJ-MSCs was characterized using and immunoblotting. The hWJ-MSC-derived OPC-like cells were able to secrete nerve growth factors and promote neurite outgrowth in vitro. These results show that hWJ-MSCs can be induced to differentiate into cells with the morphologic, phenotypic and functional characteristics of OPC-like cells. (C) 2009 International Society of Differentiation. Published by Elsevier Ltd. All rights reserved.
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