期刊
DIAGNOSTIC PATHOLOGY
卷 8, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/1746-1596-8-88
关键词
Systemic lupus erythematosus; Progranulin; Glucocorticoid; IL-6
类别
资金
- Independent Innovation Foundation of Shandong University [2012TS136]
- Eleventh Five-Year National Science and Technology Support Program [2008BA159802]
- Chinese Medical Society Clinical Research Special Fund [08010220100]
Background: This study is to investigate the expression of progranulin (PGRN) in systemic lupus erythematosus (SLE) patients and the effect of glucocorticoid (GC) treatment on its expression. Methods: Thirty newly diagnosed severe SLE patients and 30 healthy subjects were enrolled in this study. The serum levels of PGRN and the inflammatory factors of SLE were detected by ELISA and the mRNA expression of these proteins were detected by real-time PCR. Results: The serum levels of PGRN, IL-6, PR3, TNFR, TNF-alpha and anti-dsDNA antibody in SLE patients were increased significantly compared with healthy controls (P < 0.05). The relative expression of PGRN mRNA was increased by 4.88-fold in pre-treatment SLE patients compared with controls (P < 0.05). After prednisone treatment, the serum levels of PGRN decreased significantly, and the relative expression of PGRN mRNA was decreased by 1.34-fold compared with the untreated controls (P < 0.01). Moreover, Serum concentration of PGRN was correlated with serum levels of IL-6, TNF-alpha, TNFR and anti-dsDNA antibody in both pre-treatment and post-treatment SLE patients. Conclusions: PGRN is up-regulated in the SLE patients and is correlated with pro-inflammatory cytokines and anti-dsDNA antibody. Glucocorticoids can down-regulate the expression of PGRN in SLE patients. Virtual slides: http://www.diagnosticpathology.diagnomx.eu/vs/1562484036905973
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据