期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 79, 期 4, 页码 483-485出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2014.05.010
关键词
Enterobacteria; Imipenem; Carbapenemase
资金
- CONACyT (Mexican Council for Science and Technology) [136339, 130224]
The KPC-producing Klebsiella pneumoniae sequence type 258 (ST258) is an important pathogen widely spread in nosocomial infections. In this study, we identified the KPC-2-producing K. pneumoniae clinical isolates of 2 unrelated outbreaks that corresponded to pandemic strain ST258. The isolates showed high resistance to cephalosporins, carbapenems, quinolones, and colistin. The KPC-2-producing K. pneumoniae isolates were compared to the previously studied KPC-3-producing K. pneumoniae isolates from an outbreak in Mexico; they showed an unrelated pulsed-field gel electrophoresis fingerprinting pattern and a different plasmid profile. The KPC-2 carbapenemase gene was identified in two 230- and 270-kb non-conjugative plasmids; however, 1 isolate transferred the KPC-2 gene onto an 80-kb plasmid. These findings endorse the need of carrying out a continuous molecular epidemiological surveillance of carbapenem-resistant isolates in hospitals in Mexico. (C) 2014 Elsevier Inc. All rights reserved.
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