期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 73, 期 1, 页码 89-93出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2012.02.004
关键词
Candida; Osteomyelitis; Fungal; Bone; Infection
Candida osteomyelitis is a rare infection. We present 17 cases of Candida osteomyelitis from our institution and review 194 patients from the literature. The median age of patients was 57 +/- 22 years (range, 18-90 years) with 68% male. Comorbidities associated with this infection include prior surgery (62%), broad-spectrum antibiotics (40%), central venous catheter insertion (19%), and immunosuppression (17%). The most common infecting species were Candida albicans (69%), Candida tropicalis (15%), and Candida glabrata (8%). Most initial antifungal regimens included amphotericin B (59%); however, fluconazole is increasingly being utilized for treatment of this infection (26%). Echinocandins were used infrequently (4%). Median length of treatment was 3 +/- 4.5 months (mean, 4.2 months: range, 18 days to 36 months). The overall success rate of therapy was 91%, with 75% of patients cured by 6 months. The crude mortality rate was 12% with an attributable mortality rate of 6%. (C) 2012 Elsevier Inc. All rights reserved.
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