期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 73, 期 4, 页码 380-382出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2012.04.013
关键词
cfr; MRSE; ST22; fexA; Linezolid resistance
资金
- Ministerio de Ciencia e Innovacion of Spain [SAF2009-08570]
- Ministerio de Educacion y Ciencia of Spain
- Gobierno de La Rioja
The cfr gene was identified in 3 methicillin-resistant Staphylococcus epidermidis (MRSE) isolates of lineage ST22 implicated in a fatal human infection. MRSE isolates displayed an indistinguishable pulsed-field gel electrophoresis profile and SCCmec type III, and showed a multiresistance phenotype. The presence of cfr, fexA, aac(6')-aph(2 ''), and dfrS1 genes was confirmed by polymerase chain reaction and sequencing. A mutation in 23S rRNA gene (C2534T) and amino acid changes and/or insertions in 13 and L4 proteins were detected. The cfr and fexA genes were located in a conjugative plasmid of approximately 45 kb and in the chromosome. (C) 2012 Elsevier Inc. All rights reserved.
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