CEM-101, a novel fluoroketolide: antimicrobial activity against a diverse collection of Gram-positive and Gram-negative bacteria

CEM-101 is a novel fluoroketolide with reported high potency against diverse groups of Gram-positive (Micrococcus spp., viridans group streptococci, Corynebacterium spp. Listeria monocytogenes, Clostridium spp., etc.) and Gram-negative bacteria (Neisseria gonorrhoeae, Campylobacter jejuni, Helicobacter pylori, Bacteroides fragilis, Shigella spp., etc.), including mycoplasma and ureaplasma, as well as bacteria commonly associated with community-acquired respiratory tract infections and skin and skin structure infections. In this study, CEM-101 and comparator antimicrobials were tested against a collection of very low prevalence aerobic and anaerobic bacteria collected via the SENTRY Antimicrobial Surveillance Program platform. CEM-101 was highly active against all Gram-positive organisms (MIC50, 0.015 mu g/mL) as compared with telithromycin (MIC50, 0.06 mu g/mL), clarithromycin (MIC50, 0.12 mu g/mL), and erythromycin (MIC50, 0.25 mu g/mL). Among Gram-negative pathogens, CEM-101 also displayed a high potency against most strains (MIC50, 4 mu g/mL) but was found to be equivalent or less active when compared with other antimicrobials tested with MIC50 values ranging from <= 0.12 mu s/mL for levofloxacin to 8 mu g/mL for telithromycin. Among the strict anaerobic species, CEM-101 activity mirrored that of the aerobic species: high activity against the Gram-positive anaerobes (MIC50 results ranging from <= 0.03 mu g/mL to 0.12 mu g/mL) and equivalent or less susceptible against Gram-negative anaerobes. Our in vitro antimicrobial susceptibility results for CEM-101 demonstrate better activity compared with other MLSB class agents among a diverse group of uncommonly isolated bacterial pathogens; these results provide an impetus for possible expanded indications during Phase 2 and 3 clinical trials. (C) 2010 Elsevier Inc. All rights reserved.